業績

2018年

原著論文

• "Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling."
  Yuki Maruyama, Yoshihiro Toya, Hiroshi Kurokawa, Yuka Fukano, Atsushi Sato, Hiroyasu Umemura, Kaoru Yamada, Hideaki Iwasaki, Norio Tobori, Hiroshi Shimizu
  Applied Microbiology and Biotechnology 102, 20, 8909-8920 (2018).
• "A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae"
  Jun Ishii, Keisuke Morita, Kengo Ida, Hiroko Kato, Shohei Kinoshita, Shoko Hataya, Hiroshi Shimizu, Akihiko Kondo, Fumio Matsuda
  Biotechnology for Biofuels 11, 180 (2018).
• "Transcriptome analysis of the cyanobacterium Synechocystis sp. PCC 6803 and mechanisms of photoinhibition tolerance under extreme high light conditions"
  Kenichi Ogawa, Katsunori Yoshikawa, Fumio Matsuda, Yoshihiro Toya, Hiroshi Shimizu
  Journal of Bioscience and Bioengineering 126, 5, 596-602 (2018).
• "Comparative analysis of fermentation and enzyme expression profiles among industrial Saccharomyces cerevisiae strains"
  Kiyoka Uebayashi, Hiroshi Shimizu, Fumio Matsuda
  Applied Microbiology and Biotechnology 102, 16, 7071-81 (2018).
• "13C-metabolic flux analysis of ethanol-assimilating Saccharomyces cerevisiae for S-adenosyl-L-methionine production"
  Kenshi Hayakawa, Fumio Matsuda, Hiroshi Shimizu
  Microbial Cell Factories 17, 82 (2018).
• "Comparative Targeted Proteomics of the Central Metabolism and Photosystems in SigE Mutant Strains of Synechocystis sp. PCC 6803"
  Yuma Tokumaru, Kiyoka Uebayashi, Masakazu Toyoshima, Takashi Osanai, Fumio Matsuda, Hiroshi Shimizu
  Molecules 23, 5, 1051 (2018).
• "Mass spectrometry-based method to study inhibitor-induced metabolic redirection in the central metabolism of cancer cells"
  Chie Araki, Nobuyuki Okahashi, Kousuke Maeda, Hiroshi Shimizu, Fumio Matsuda
  Mass Spectrometry 7, 1, A0067 (2018).
• "Expression of Saccharomyces cerevisiae cDNAs to enhance the growth of non-ethanol-producing S. cerevisiae strains lacking pyruvate decarboxylases"
  Yuki Narazaki, Yuta Nomura, Keisuke Morita, Hiroshi Shimizu, Fumio Matsuda
  Journal of Bioscience and Bioengineering 126, 3, 317-321 (2018).
• "Metabolic engineering of a mevalonate-producing Escherichia coli strain based on thermodynamic analysis"
  Hikaru Nagai, Ami Masuda, Yoshihiro Toya, Fumio Matsuda, Hiroshi Shimizu
  Metabolic Engineering 47, 43474 (2018).
• "Application of adaptive laboratory evolution to overcome a flux limitation in an Escherichia coli production strain"
  Kento Tokuyama, Yoshihiro Toya, Takaaki Horinouchi, Chikara Furusawa, Fumio Matsuda, Hiroshi Shimizu
  Biotechnology and Bioengineering 115, 6, 1542-1551 (2018).
• "Integrated analysis of transcriptome and metabolome of Corynebacterium glutamicum during penicillin-induced glutamic acid production"
  Takashi Hirasawa, Masaki Saito, Katsunori Yoshikawa, Chikara Furusawa, Hiroshi Shimizu
  Biotechnology Journal 13, 5, e1700612 (2018).
• "Metabolic flux of the oxidative pentose phosphate pathway under low light conditions in Synechocystis sp. PCC 6803"
  Kentaro Ueda, Tsubasa Nakajima, Katsunori Yoshikawa, Yoshihiro Toya, Fumio Matsuda, Hiroshi Shimizu
  Journal of Bioscience and Bioengineering 126, 1, 38-43 (2018).
• "Optimal 13C-labeling of glycerol carbon source for precise flux estimation in Escherichia coli"
  Yoshihiro Toya, Shugo Ohashi, Hiroshi Shimizu
  Journal of Bioscience and Bioengineering 125, 3, 301-305 (2018).

総説､解説

• "Editorial overview: Recent progress in analytical technologies for design-build-test-learn cycle in biotechnology"
  Hiroshi Shimizu, Fumio Matsuda
  Current Opinion in Biotechnology 54, 145-147 (2018).

学位論文

• "Genome-scale metabolic design for improved target production of Escherichia coli based on flux balance analysis"
  徳山 健斗
  (2018).
• "13C代謝フラックス解析に基づいた微生物のNADPH再生および消費の収支に関する研究"
  和田圭介
  (2018).

著書

• "第25章 培養動物細胞の13C代謝フラックス解析"
  岡橋 伸幸, 松田 史生, 清水 浩
  代謝センシング-健康,食,美容,薬,そして脳の代謝を知る- (シーエムシー出版), 218-228 (2018).