業績

2025年

原著論文

• "Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells"
  Nobuyuki Okahashi*, Tomoki Shima, Yuya Kondo, Chie Araki, Shuma Tsuji, Akane Sawai, Hikaru Uehara, Susumu Kohno, Hiroshi Shimizu, Chiaki Takahashi, and Fumio Matsuda,*
  Metabolic Engineering 92, 185-191 (2025).

  • DOI: https://doi.org/10.1016/j.ymben.2025.08.002
• "RB1 controls differentiation through positive regulation of phosphoglycerate mutases"
  Susumu Kohno, Nobuyuki Okahashi, Yuansong Wan, Hai Yu, Yujiro Takegami, Paing Linn, Naoko Nagatani, Shunsuke Kitajima, Teruo Kawada, Fumio Matsuda, Hiroshi Shimizu, Chiaki Takahashi*
  Cell Death and Disease 16, 559 (2025).

  • DOI: https://doi.org/10.1038/s41419-025-07850-3
• "Efficient selection of pyruvate decarboxylase sequences from database for high ethanol productivity in Synechocystis sp. PCC 6803"
  Hiroki Nishiguchi, Teppei Niide, Yoshihiro Toya, Hiroshi Shimizu
  Journal of Bioscience and Bioengineering 143, 3, 123-131 (2025).

  • DOI: https://doi.org/10.1016/j.jbiosc.2025.05.011
• "Glycolaldehyde affects the growth of and metabolic flux distribution in Synechocystis sp. PCC 6803"
  Tatsumi Imada, Yoshihiro Toya, Hiroshi Shimizu
  Bioscience, Biotechnology, and Biochemistry 89, 7, 995-997 (2025).

  • DOI: https://doi.org/10.1093/bbb/zbaf046
• "Engineering anaerobic electron flow through heterologous rhodoquinone synthesis in model microbial and photosynthetic platforms"
  Haruki Sasaki, Yuri Yanagihara, Yui Satofuka, Masaki Hasegawa, Yuichiro Kashiyama, Kimitoshi Sakamoto, Yoshihiro Toya, Hiroshi Shimizu, Takayuki Fujiwara, Shin’ya Miyagishima, Mitsuhiro Ueda, Tatsuji Sakamoto, Masami Nakazawa
  Journal of Bioscience and Bioengineering 140, 14-20 (2025).

  • DOI: https://doi.org/10.1016/j.jbiosc.2025.04.008
• "13C-metabolic flux analysis of respiratory chain disrupted strain ΔndhF1 of Synechocystis sp. PCC 6803 "
  Keisuke Wada, Yoshihiro Toya, Fumio Matsuda, Hiroshi Shimizu
  Applied Biochemistry and Biotechnology, in press (2025).

  • DOI: 10.1007/s12010-024-05138-4
• "Growth inhibition by ppc deletion is rescued by isocitrate dehydrogenase mutations in Escherichia coli"
  Yoshihiro Toya, Tatsumi Imada, Mai Ishibashi, Yuichi Kawamoto, Kinuka Isshiki, Atsushi Shibai, Chikara Furusawa, Hiroshi Shimizu
  FEMS Microbiology Letters 372, fnaf013 (2025).

  • DOI: 10.1093/femsle/fnaf013
• "Modification of intracellular metabolism by expression of a C-terminal variant of phosphoribulokinase from Synechocystis sp. PCC 6803"
  Hiroki Nishiguchi, Teppei Niide, Yoshihiro Toya, Hiroshi Shimizu
  Bioscience, Biotechnology, and Biochemistry, in press (2025).

  • DOI: 10.1093/bbb/zbaf013

総説､解説

• "代謝経路におけるフラックス分布の評価と最適化"
  戸谷吉博
  生物工学 103, 7, 288-291 (2025).

  • DOI: https://doi.org/10.34565/seibutsukogaku.103.7_288

学位論文

• "Effect of Non-Oxidative Glycolysis Introduction on Target Production by Escherichia coli （大腸菌の物質生産における非酸化的解糖経路導入の効果に関する研究）"
  三吉健太
  (2025).

著書

• "AIとバイオの融合最前線、（第4章８節代謝改変のための計算手法を援用した酵素基質特異性の調節と新機能開拓）"
  二井手哲平、戸谷吉博、清水浩
  CMC出版 (2025).

その他

• "代謝の再構築デザインと評価による微生物モノづくりへの展開　特集に寄せて"
  清水浩
  (2025).

  • DOI: https://doi.org/10.34565/seibutsukogaku.103.7_284
• "ご挨拶、100年先も輝く生物工学会の基盤を築く"
  生物工学 103, 6, 227 (2025).

  • DOI: https://doi.org/10.34565/seibutsukogaku.103.6_227