2024年
原著論文
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"A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes."
Yujiro Hirose, Daniel C Zielinski, Saugat Poudel, Kevin Rychel, Jonathon L Baker, Yoshihiro Toya, Masaya Yamaguchi, Almut Heinken, Ines Thiele, Shigetada Kawabata, Bernhard O Palsson, Victor Nizet
mSystems (2024).
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"Engineering Escherichia coli for efficient glutathione production"
Hiroki Mori, Misato Matsui, Takahiro Bamba, Yoshimi Hori, Sayaka Kitamura, Yoshihiro Toya, Ryota Hidese, Hisashi Yasueda, Tomohisa Hasunuma, Hiroshi Shimizu, Naoaki Taoka, Shingo Kobayashi
Metabolic Engineering 84, 180-190 (2024).
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総説、解説
学位論文
著書
2023年
原著論文
総説、解説
著書
2022年
原著論文
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"Conversion of mevalonate to isoprenol using light energy in Escherichia coli without consuming sugars for ATP supply"
Mikoto Sano, Ryo Tanaka, Kentaro Kamata, Yoko Hirono-Hara, Jun Ishii, Fumio Matsuda, Kiyotaka Y Hara, Hiroshi Shimizu, Yoshihiro Toya
ACS Synthetic Biology 11, 12, 3966–3972 (2022).
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"Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production."
Junya Yamamoto, Onuma Chumsakul, Yoshihiro Toya, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Takashi Hirasawa, Fumio Matsuda, Naotake Ogasawara, Hiroshi Shimizu, Ken-ichi Yoshida, Taku Oshima, Shu Ishikawa
DNA Research 29, 3, 44574 (2022).
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"Optogenetic reprogramming of carbon metabolism using light-powering microbial proton pump systems"
Yoshihiro Toya, Yoko Hirono-Hara, Hidenobu Hirayama, Kentaro Kamata, Ryo Tanaka, Mikoto Sano, Sayaka Kitamura, Kensuke Otsuka, Rei Abe-Yoshizumi, Satoshi P Tsunoda, Hiroshi Kikukawa, Hideki Kandori, Hiroshi Shimizu, Fumio Matsuda, Jun Ishii, Kiyotaka Y Hara
Metabolic Engineering 72, 227-236 (2022).
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"Acceleration of target production in co-culture by enhancing intermediate consumption through adaptive laboratory evolution"
Ryutaro Kawai, Yoshihiro Toya, Kenta Miyoshi, Manami Murakami, Teppei Niide, Takaaki Horinouchi, Tomoya Maeda, Atsushi Shibai, Chikara Furusawa, Hiroshi Shimizu
Biotechnology and Bioengineering 119, 3, 936-945 (2022).
総説、解説
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"データサイエンス駆動型リジン発酵プロセス予測モデリング"
徳山 健斗, 下平 祥貴, 寺脇 貴弘, 楠瀬 泰弘, 中井 裕章, 辻 雄一郎, 戸谷 吉博, 松田 史生, 清水 浩
生物工学会誌 100, 2, 80 (2022).
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その他
2021年
原著論文
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"Soft-sensor development for monitoring the lysine fermentation process"
Kento Tokuyama, Yoshiki Shimodaira, Yohei Kodama, Ryuzo Matsui, Yasuhiro Kusunose, Shunsuke Fukushima, Hiroaki Nakai, Yuichiro Tsuji, Yoshihiro Toya, Fumio Matsuda, Hiroshi Shimizu
Journal of Bioscience and Bioengineering 132, 2, 183-189 (2021).
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"Treatment of RB1-intact hepatocellular carcinoma with CDK4/6 inhibitor combination therapy"
Jindan Sheng, Susumu Kohno, Nobuhiro Okada, Nobuyuki Okahashi, Kana Teranishi, Fumio Matsuda, Hiroshi Shimizu, Paing Linn, Naoko Nagatani, Minako Yamamura, Kenichi Harada, Shin-ichi Horike, Hiroshi Inoue, Seiji Yano, Sharad Kumar, Shunsuke Kitajima, Itsuki Ajioka, Chiaki Takahashi
Hepatology (2021).
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総説、解説
学位論文
著書
2020年
原著論文
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"Data science-based modeling of the lysine fermentation process"
Kento Tokuyama, Yoshiki Shimodaira, Takahiro Terawaki, Yasuhiro Kusunose, Hiroaki Nakai, Yuichiro Tsuji, Yoshihiro Toya, Fumio Matsuda, Hiroshi Shimizu
Journal of Bioscience and Bioengineering 130, 4, 409-415 (2020).
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総説、解説
学位論文
2019年
原著論文
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"High-yielding rice Takanari has superior photosynthetic response under fluctuating light to a commercial rice Koshihikari"
Shunsuke Adachi, Yu Tanaka, Atsuko Miyagi, Makoto Kashima, Ayumi Tezuka, Yoshihiro Toya, Shunzo Kobayashi, Satoshi Ohkubo, Hiroshi Shimizu, Maki Kawai-Yamada, Rowan F Sage, Atsushi J Nagano, Wataru Yamori
Journal of Experimental Botany 70, 19, 5287-5297 (2019).
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"Targeted proteome analysis of microalgae under high-light conditions by optimized protein extraction of photosynthetic organisms"
Masakazu Toyoshima, Masumi Sakata, Kazuki Ohnishi, Yuma Tokumaru, Yusuke Kato,Ryutaro Tokutsu, Wataru Sakamoto, Jun Minagawa, Fumio Matsuda, Hiroshi Shimizu
Journal of Bioscience and Bioengineering 127, 3, 394-402 (2019).
総説、解説
学位論文
2018年
原著論文
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"Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling."
Yuki Maruyama, Yoshihiro Toya, Hiroshi Kurokawa, Yuka Fukano, Atsushi Sato, Hiroyasu Umemura, Kaoru Yamada, Hideaki Iwasaki, Norio Tobori, Hiroshi Shimizu
Applied Microbiology and Biotechnology 102, 20, 8909-8920 (2018).
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"A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae"
Jun Ishii, Keisuke Morita, Kengo Ida, Hiroko Kato, Shohei Kinoshita, Shoko Hataya, Hiroshi Shimizu, Akihiko Kondo, Fumio Matsuda
Biotechnology for Biofuels 11, 180 (2018).
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総説、解説
学位論文
著書
2017年
原著論文
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"The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity"
Shunsuke Kitajima, Akiyo Yoshida, Susumu Kohno, Sawako Suzuki, Naoko Nagatani, Fengkai Li, Yuuki Nishimoto, Nobunari Sasaki, Hayato Muranaka, Yuansong Wan, Tran Thai, Nobuyuki Okahashi, Fumio Matsuda, Hiroshi Shimizu, Takumi Nishiuchi, Yutaka Suzuki, Kana Tominaga, Noriko Gotoh, Misa Suzuki, Mark Ewen, David Barbie, Osamu Hirose, Tomoaki Tanaka, Chiaki Takahashi
Oncogene 36, 36, 5145-5157 (2017).
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総説、解説
学位論文
著書
-
"Chapter 7, Omics integrations for the state analysis of microbial processes"
Hiroshi Shimizu, Chikara Fursawa, Takashi Hirasawa, Katsunori Yoshikawa, Yoshihiro Toya, Tomokazu Shirai, Fumio Matsuda
BIOTECHNOLOGY, Wiley-VCH book series, Weinheim, Vol 5: Applied Bioengineering: Innovations and Future Directions, 201-236 (2017).
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2016年
原著論文
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"Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer"
Miyo Masaaki, Konno Masamitsu, Nishida Naohiro, Sueda Toshinori, Noguchi Kozo, Matsui Hidetoshi, Colvin Hugh, Kawamoto Koichi, Koseki Jun, Haraguchi Naotsugu, Nishimura Junichi, Hata Taishi, Gotoh Noriko, Matsuda Fumio, Satoh Taroh, Mizushima Tsunekazu, Shimizu Hiroshi, Doki Yuichiro, Mori Masaki, Ishii Hideshi
Scientific Reports 6, 38415 (2016).
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総説、解説
著書
2015年
原著論文
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"Enhanced dipicolinic acid production during the stationary phase
in Bacillus subtilis by blocking acetoin synthesis"
Yoshihiro Toya, Takashi Hirasawa, Shu Ishikawa, Onuma Chumsakul, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Katsuya Ozaki, Naotake Ogasawara, Hiroshi Shimizu
Bioscience, Biotechnology, and Biochemistry 79, 12, 2073-80 (2015).
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総説、解説
学位論文
2014年
原著論文
総説、解説
著書
2013年
原著論文
総説、解説
学位論文
2012年
原著論文
総説、解説
著書
2011年
原著論文
総説、解説
学位論文
2010年
原著論文
総説、解説
学位論文
2009年
原著論文
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"Systematic phenome analysis of Escherichia coli multiple‐knockout mutants reveals hidden reactions in central carbon metabolism"
Kenji Nakahigashi,Yoshihiro Toya, Nobuyoshi Ishii, Tomoyoshi Soga, Miki Hasegawa, Hisami Watanabe, Yuki Takai, Masayuki Honma, Hirotada Mori, Masaru Tomita
Molecular Systems Biology 5, 1, 306 (2009).
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総説、解説
学位論文
2008年
原著論文
総説、解説
学位論文
著書
2007年
原著論文
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"Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis"
Yoshihiro Toya, Nobuyoshi Ishii, Takashi Hirasawa, Miki Naba, Kenta Hirai, Kaori Sugawara, Saori Igarashi, Kazuyuki Shimizu, Masaru Tomita, Tomoyoshi Soga
Journal of Chromatography 1159, 134-141 (2007).
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"Multiple high throughput analyses monitor the response of E. coli to perturbations"
Nobuyoshi Ishii, Kenji Nakahigashi, Tomoya Baba, Martin Robert, Tomoyoshi Soga, Akio Kanai, Takashi Hirasawa, Miki Naba, Kenta Hirai, Aminul Hoque, Pei Yee Ho, Yuji Kakazu, Kaori Sugawara, Saori Igarashi, Satoshi Harada, Takeshi Masuda, Naoyuki Sugiyama, Takashi Togashi, Miki Hasegawa, Yuki Takai, Katsuyuki Yugi, Kazuharu Arakawa, Nayuta Iwata, Yoshihiro Toya, Yoichi Nakayama, Takaaki Nishioka, Kazuyuki Shimizu, Hirotada Mori, Masaru Tomita
Science 316, 5824, 593-597 (2007).
総説、解説
学位論文
著書
2006年
原著論文
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"Comparative analysis of transcriptional responses to saline stress in the laboratory and brewing strains of Saccharomyces cerevisiae with DNA microarray"
Takashi Hirasawa, Yuki Nakakura, Katsunori Yoshikawa, Kengo Ashitani, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Hiroshi Shimizu, Suetaki Shioya
Applied Microbiology and Biotechnology 70, 3, 346-357 (2006).
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総説、解説
著書
2005年
原著論文
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"Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria"
Tomokazu Shirai, Akinori Nakato, Noriyuki Izutani,Keisuke Nagahisa, Suteaki Shioya, Eiichiro Kimura,Yutaka Kawarabayashi, Akihiko Yamagishi, Takashi Gojobori, Hiroshi Shimizu
Metabolic Engineering 7, 2, 59-69 (2005).
総説、解説
著書
2004年
総説、解説
著書
2003年
原著論文
総説、解説
2002年
原著論文